Comparison 20. Appendix 5: lithium vs olanzapine ‐ single trial data and less common adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Tremor	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.48 [0.04, 5.40]
2 Any adverse event	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.60 [0.31, 1.16]
3 Nausea	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	1.86 [0.59, 5.85]
4 Constipation	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.29 [0.08, 1.14]
5 Nasopharyngitis	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.97 [0.23, 4.04]
6 Somnolence	1	123	Odds Ratio (M‐H, Fixed, 95% CI)	0.27 [0.05, 1.46]
7 Vomiting	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.72 [0.15, 3.33]
8 Diarrhoea	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.47 [0.08, 2.66]
9 Dizziness	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.47 [0.08, 2.66]
10 Cough	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.97 [0.13, 7.09]
11 Restlessness	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.01, 1.93]
12 Tachycardia	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.31 [0.03, 3.10]
13 Fatigue	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.13 [0.01, 2.62]
14 Headache	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.48 [0.04, 5.40]
15 Increased appetite	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.13 [0.01, 2.62]
16 Tonsillitis	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	1.97 [0.17, 22.25]
17 URTI	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	1.97 [0.17, 22.25]
18 Dry Mouth	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.19 [0.01, 4.00]
19 Gingivitis	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	5.0 [0.24, 106.05]
20 Haemorrhoids	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.19 [0.01, 4.00]
21 Adverse effects possibly related to drug use	1	123	Odds Ratio (M‐H, Fixed, 95% CI)	0.27 [0.12, 0.59]
22 Metabolism and nutrition disorders	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.23 [0.03, 2.13]
23 Nervous system disorders	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.40 [0.12, 1.36]
24 Abnormal hepatic function	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	2.96 [0.12, 73.85]
25 EPSE	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	1.97 [0.17, 22.25]
26 Significant high cholesterol	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.31 [0.03, 3.10]
27 Significant high glucose	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.32 [0.01, 7.97]
28 Weight gain > 7%	1	140	Odds Ratio (M‐H, Fixed, 95% CI)	6.14 [1.31, 28.83]