Comparison 22. Appendix 7: lithium vs chlorpromazine ‐ adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Toxicity	1	118	Odds Ratio (M‐H, Fixed, 95% CI)	1.42 [0.36, 5.58]
2 Intercurrent illness	1	255	Odds Ratio (M‐H, Fixed, 95% CI)	0.74 [0.16, 3.37]
3 Side effects total: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.35 [0.13, 0.92]
4 Side effects total: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	1.98 [0.86, 4.56]
5 Anorexia: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	4.56 [0.21, 96.77]
6 Anorexia: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	8.24 [0.42, 162.91]
7 Nausea: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	4.56 [0.21, 96.77]
8 Nausea: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	10.78 [0.57, 204.68]
9 Vomiting: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	4.56 [0.21, 96.77]
10 Vomiting: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	5.78 [0.27, 122.94]
11 Diarrhoea: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	3.41 [0.14, 85.34]
12 Dry mouth: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.28 [0.03, 2.81]
13 Dry mouth: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	0.55 [0.05, 6.25]
14 Constipation: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.12 [0.01, 2.38]
15 Constipation: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	5.78 [0.27, 122.94]
16 Abdominal pain: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	1.12 [0.07, 18.33]
17 Muscle weakness: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.29 [0.01, 7.26]
18 Ataxia: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	3.48 [0.35, 34.43]
19 Tremor: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	4.56 [0.21, 96.77]
20 Tremor: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	7.36 [0.86, 63.04]
21 Facial twitching; highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	3.41 [0.14, 85.34]
22 Parkinsonism: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	3.41 [0.14, 85.34]
23 Somnolence: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.16 [0.02, 1.45]
24 Somnolence; highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	0.54 [0.13, 2.25]
25 Confusion: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	3.69 [0.40, 33.97]
26 Confusion: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	3.48 [0.35, 34.43]
27 Slurred speech: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.12 [0.01, 2.38]
28 Slurred speech: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	1.12 [0.07, 18.33]
29 Blurred vision: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.29 [0.01, 7.26]
30 Dizziness: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.17 [0.01, 3.64]
31 Dizziness: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	3.41 [0.14, 85.34]
32 Seizures: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	3.41 [0.14, 85.34]
33 Hypotensive reaction: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.12 [0.01, 2.38]
34 Hypotensive reaction: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	0.37 [0.01, 9.18]
35 Pruritus: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	3.41 [0.14, 85.34]
36 Polyuria: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	2.69 [0.11, 67.35]
37 Severe reaction: mildly active group	1	130	Odds Ratio (M‐H, Fixed, 95% CI)	0.35 [0.13, 0.92]
38 Severe reaction: highly active group	1	125	Odds Ratio (M‐H, Fixed, 95% CI)	1.98 [0.86, 4.56]