Fig. 1.

The role of neutrophils in the early metastatic cascade – primary tumour progression and invasion.

NE, neutrophil elastase; Arg1, arginase 1; TGFβ, Transforming growth factor beta; EMT, epithelial-mesenchymal transition; Zeb1, Zinc finger E-box-binding homeobox 1; Twist, Twist-related protein 1; MMP, matrix metalloproteinase; ECM, extracellular matrix; VEGF, Vascular endothelial growth factor; HOCL, Hypochlorous acid; TIMP, tissue inhibitor of metalloproteinases; ADAMs, a disintegrin and metalloproteinase; G-CSF, Granulocyte-colony stimulating factor; CXCL, Chemokine (C-X-C motif) ligand; CCL, Chemokine (C-C motif) ligand; VE-cadherin, vascular endothelial cadherin.