Exposure to d- and l-amphetamine was not altered by consuming a high-fat meal before taking SHP465 mixed amphetamine salts (MAS) or by sprinkling the contents of a SHP465 MAS capsule over applesauce, demonstrating that SHP465 MAS capsules can be swallowed whole with or without food or the contents of an SHP465 MAS capsule can be sprinkled on applesauce.

SHP465 MAS was generally well tolerated when administered as a single 50-mg dose in healthy adults, with a profile that was consistent with previously reported effects in adults with attention-deficit/hyperactivity disorder.