Table 1.
Top 20 genes differentially expressed in PBMCs of tgDISC1 rats compared with littermate controls
| Entry name | Gene symbol [rat] | Gene symbol [human] | Protein name | TG versus LM | qPCR performed | ||||
|---|---|---|---|---|---|---|---|---|---|
| Change | FC | P | rat | human | |||||
| 1 | RGS1_RAT | Rgs1 | RGS1 | Regulator of G-protein signaling 1 | ↓ | 2.03 | 0.0062 | Y | Y |
| 2 | CCL4_RAT | Ccl4 | CCL4 | Chemokine (C–C motif) ligand 4 | ↓ | 1.67 | 0.0001 | Y | Y |
| 3 | D4A8L8_RAT | Fpr2|Fpr2l | FPR2 | Formyl peptide receptor 2 | Formyl peptide receptor 2-like | ↓ | 1.65 | 0.0053 | n.d. | Y |
| 4 | CO3_RAT | C3 | C3 | Complement component 3 | ↓ | 1.63 | 0.0037 | Y | Y |
| 5 | Q9WVL9_RAT | Nkg7 | NKG7 | Natural killer cell group 7 | ↓ | 1.60 | 0.0004 | Y | Y |
| 6 | F1LRH7_RAT | Il12rb2 | IL12RB2 | Interleukin 12 receptor, beta 2 | ↓ | 1.59 | 0.0095 | Y | Y |
| 7 | ILEUA_RAT | Serpinb1a | SERPINB1 | Serine proteinase inhibitor, clade B, member 1a | ↓ | 1.52 | 0.0071 | Y | Y |
| 8 | Q5MPU9_RAT | Ly49si3 | – | Immunoreceptor Ly49si2 | ↓ | 1.51 | 0.0060 | n.d. | n.d. |
| 9 | Q5M7T7_RAT | Pla2g7 | PLA2G7 | Phospholipase A2, group VII | ↓ | 1.48 | 0.0056 | n.d. | n.d. |
| 10 | H2A2A_RAT | LOC690131|Hist2h2aa3 | HIST2H2AA3 | Similar to H2A histone family, member O | Histone cluster 2, H2aa3 | ↓ | 1.47 | 0.0002 | n.d. | n.d. |
| 11 | Q66HN6_RAT | Slc27a2 | SLC27A2 | Solute carrier family 27 (fatty acid transporter), member 2 | ↓ | 1.46 | 0.0089 | Y | Y |
| 12 | Q561K3_RAT | Il13ra1 | IL13RA1 | Interleukin 13 receptor, alpha 1 | ↓ | 1.45 | 0.0074 | Y | Y |
| 13 | CP4F3_RAT | Cyp4f18 | CYP4F2 | Cytochrome P450, family 4, subfamily f, polypeptide 18 | ↓ | 1.44 | 0.0038 | n.d. | n.d. |
| 14 | RL10_RAT | Rpl10 | RPL10 | Ribosomal protein L10 | ↓ | 1.41 | 0.0059 | n.d. | n.d. |
| 15 | D3ZPB4_RAT | Olr428 | OR1L6 | Olfactory receptor 428 | ↑ | 1.41 | 0.0092 | n.d. | n.d. |
| 16 | IFNG_RAT | Ifng | IFNG | Interferon gamma | ↓ | 1.38 | 0.0014 | Y | Y |
| 17 | D1MF50_RAT |
RGD 1561778 |
CD300C | Similar to dendritic cell-derived immunoglobulin-like receptor 1 | ↓ | 1.38 | 0.0055 | n.d. | n.d. |
| 18 | F1LYV1_RAT | Scimp | SCIMP | SLP adaptor and CSK interacting membrane protein | ↓ | 1.37 | 0.0018 | n.d. | n.d. |
| 19 | TSN31_RAT | Tspan31 | TSPAN31 | Tetraspanin 31 | ↓ | 1.36 | 0.0041 | n.d. | n.d. |
| 20 | D4AC93_RAT | Tmem223 | TMEM223 | Transmembrane protein 223 | ↓ | 1.35 | 0.0050 | n.d. | n.d. |
Arrow down, reduced expression in tgDISC1 rats, arrow up, increased expression in tgDISC1 rats. FC fold change, qPCR quantitative real-time PCR, n.d. not determined, Y qPCR performed (yes), LM non-transgenic littermate control, TG tgDISC1 rat