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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Echocardiography. 2018 Mar 30;35(7):922–934. doi: 10.1111/echo.13871

Figure 2. Standardized mean difference (SMD) and 95% confidence intervals of global longitudinal strain (GLS) between patients at baseline (prior to anthracyclines) and patients within one year of anthracycline treatment.

Figure 2.

The size of the square marker is proportional to the weight assigned to each study in the pooled estimate (diamond) using a random effects model. The weighing is related to the inverse of the standard error (and therefore indirectly to the sample size) reported in the studies. Studies with smaller standard error and larger sample size are given more weight in calculating the pooled effect size. SMD Total (fixed effects) = −0.714; SMD Total (random effects) = −0.788 (both p<0.001). Level II evidence. There was no statistically significant difference among the findings of the included 6 articles [27–31,33] (X2 (5)=10.32, p=0.067), and the inconsistency among included articles was quantified as I2=51.56% [95% CI=0–80.7]. The reported decreases in GLS after treatment based on the 6 included papers [27–31,33] are moderately heterogeneous. Doses are reported as mean ± SD unless noted otherwise. aaverage; bmedian.