. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Echocardiography. 2018 Mar 30;35(7):922–934. doi: 10.1111/echo.13871

TABLE 3.

Summary of studies evaluating patients at >10 years following anthracycline therapy.

Study	Patient Age (years)	Timing of Measurements (years)	Anthracycline Dose (mg/m²)	Cancer Type	Software	Post-chemotherapy^c	Controls^c
Cheung et al⁴⁴	24.1 ± 4.2	15.3 ± 5.8	218 ± 98	ALL, AML	EchoPAC, GE	GLS: −16.0 ± 3.1	GLS: −17.1 ± 3.2
						GCS: −14.3 ± 3.5	GCS: −16.6 ± 4.7
						GRS: 32.9 ± 10.9	GRS: 42.3 ± 12.5
Dietz et al⁴⁵	27 [18 – 50]	17 [5 – 30]	440 [300 – 645]	OS, RMS, ES, SS, LY, WT	QLAB quantification, Phillips	Radial displacement: 5.61 ± 1.16	Radial displacement: 6.73 ± 1.52
Mavinkurve-Groothuis et al⁴⁶	20 [5.6 – 37.4]	13.2 [5 – 29.2]	180 [50 – 600]	ALL, AML, EP, ES, HB, HL, NC, NB, nHL, OS, RMS, WT	EchoPAC, GE	GLS: −19.8 ± 2.6	GLS: −21.2 ± 1.6
						GCS: −15.9 ± 6.7	GCS: −22.6 ± 2.1
						GRS: 49 ± 12	GRS: 57 ± 5
Yu et al^{48, b}	31 [18 – 62]	15 [2 – 39]	300 [27 – 660]	SA, HL, ALL, AML, nHL	EchoPAC 12.0, GE	Anthracycline alone:	-
						GLS: 19 [17 – 20]
						GCS: 17.6 [16 – 19.7]
						GRS: 42.0 [31.9 – 51.4]
						Anthracycline and radiation:
						GLS: 18 [16 – 19.5]
						GCS: 16.1 [14.5 – 19.7]
						GRS: 42.1 [26.5 – 55.2]
Armstrong et al⁴⁷	31 [18 – 65]	22.6 [10.4 – 48.3]	Median not given [0 – 600]	LE, ALL, AML, LY, nHL, HL, CNS tumor, Bone tumor, ES, OS, Soft tissue SA, RMS, Nonrhabdo SA, GC, Melanoma, NB, RB, WT, Carcinoma, Other	EchoPAC, GE	Anthracycline alone:	-
						GLS: −19.3 ± 2.6
						GCS: −20.2 ± 5.0
						Anthracyclines and radiation:
						GLS: −18.5 ± 2.8
						GCS: −20.1 ± 5.0
Christiansen et al^{49, a}	28.6 [18.6 – 46.5]	23.4 [7.4 – 40]	Low dose: 120 [40 – 120], Mod-high dose: 240 [173 – 485]	ALL	EchoPAC 7, GE	Low dose:	Low dose:
						GLS: −18.1 ± 2.3	GLS: −19.7 ± 2.4
						Moderate dose:	Moderate dose:
						GLS: −18.3 ±1.9	GLS: −19.7 ± 2.4

ALL=acute lymphoblastic leukemia; AML=acute myeloid leukemia; EP=ependymoma; ES=Ewing sarcoma; GC=germ cell tumor; HB=hepatoblastoma; HL=Hodgkin lymphoma; LE=leukemia; LY=lymphoma; NB=neuroblastoma; NC=nasopharyngeal carcinoma; nHL=non-Hodgkin lymphoma; OS=osteosarcoma; RB=retinoblastoma; RMS=rhabdomyosarcoma; SA=sarcoma; SS=synovial sarcoma; WT=Wilms tumor.

comparison group consists of anthracycline naïve cancer survivors.

absolute strain values provided.

units, strain measurements (%), radial displacement (mm).