Comparison 2. EC/IC bypass versus best medical treatment: all studies.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Death from all causes	19	900	Odds Ratio (M‐H, Fixed, 95% CI)	1.00 [0.62, 1.62]
2 Any stroke during follow up	18	881	Odds Ratio (M‐H, Fixed, 95% CI)	0.80 [0.54, 1.18]
3 Death or dependency	8	346	Odds Ratio (M‐H, Fixed, 95% CI)	0.80 [0.50, 1.29]
4 Vascular death	19	900	Odds Ratio (M‐H, Fixed, 95% CI)	0.95 [0.56, 1.63]
5 Stroke, serious vascular events or vascular death	13	673	Odds Ratio (M‐H, Fixed, 95% CI)	0.69 [0.45, 1.04]
6 Myocardial infarction	2	79	Odds Ratio (M‐H, Fixed, 95% CI)	2.67 [0.41, 17.60]
7 Ischaemic stroke	13	640	Odds Ratio (M‐H, Fixed, 95% CI)	0.72 [0.44, 1.18]
8 Intracranial haemorrhage	4	361	Odds Ratio (M‐H, Fixed, 95% CI)	1.14 [0.44, 2.93]
9 Transient ischaemic attack or amaurosis fugax	11	524	Odds Ratio (M‐H, Fixed, 95% CI)	0.34 [0.16, 0.69]
10 Normalisation of cerebral haemodynamics	3	56	Odds Ratio (M‐H, Fixed, 95% CI)	6.63 [1.85, 23.78]