| Methods |
Parallel design. Due to the randomisation method was not mentioned in original article, we telephone interviewed the original author. The randomisation method was made clear that allocation sequence was generated by random number table. No blindness. |
| Participants |
All patients included were inpatients or outpatients who were diagnosed as hyperthyroidism by clinical and laboratory examination. 32 cases were in the intervention group (M/F=8/24, aged between 15 and 61, 26+/‐9.8 years old on average, with the length of disease between 2 and 36 months, 14+/‐5.2 months on average). 30 cases were in the control group (M/F=7/23, aged between 19 and 57, 25+/‐9.2 years old on average, with the length of disease between 2 and 24 months, 12+/‐5.6 months on average). Baseline of two groups were similar. |
| Interventions |
Yikang Wan and Tapazole was used in the intervention group, Yikang Wan: p.o., 1 pill(9 g) each time, t.i.d., Tapazole: p.o., 5 mg each time, t.i.d. Tapazole was used in the control group, p.o., 5 mg each time, t.i.d. Propranolol (10 mg each time, t.i.d.) and Jiazhuangxian Pian (30 mg each time, q.d.) was used in both groups. |
| Outcomes |
The outcomes were evaluated by clinical symptoms, signs, blood routine test, FT3, FT4, TT4, TT3 concentration. They were examined 2, 3, 4 weeks after the treatment and before the treatment.
1. The hyperthyroidism diagnoses index of the intervention group was lower than the control group. There was statistical significance;
2. Two and three weeks after treatment, FT3 concentration of the intervention group turned to be normal, while FT3 concentration of the control group was still above the normal level;
3. FT4 concentration of 21 cases in the intervention group turned to be normal, while only 7 cases in the control group was normal;
4. TT3 concentration of 18 cases in the intervention group turned to be normal, while no one in the control group turned to be normal;
5. TT4 concentration of 27 cases in the intervention group turned to be normal, while 18 cases in the control group turned normal;
6. Adverse effect: temple WBC increasing was observed in 3 cases in the intervention group and 5 cases in the control group. Taking drugs that could increase WBC, the symptom subsided and the cases continued the study. |
| Notes |
1. Yikang Wan was provided by the company that was the sponsor of the magazine in which the article was published;
2. There was potential conflict of interest in the study. |
