| Methods |
Parallel design. Due to the randomisation method wasn't mentioned in original article, we telephone interviewed the original author. The randomisation method was made clear that allocation sequence was generated by random number table. No blindness. |
| Participants |
105 in‐patients of hyperthyroidism were included. 62 cases were in intervention group (M/F=22/40, aged between 15 and 57, 29.1+/‐10.8 years old on average). 43 cases were in control group (M/F=14/29, aged between 14 and 56, 28.3+/‐11.2 years old on average). Baseline of two groups were similar. |
| Interventions |
Tapazole was used in both groups, 30 mg/day, for 28 days. Besides tapazole, Chinese medicine was additionally used in the intervention group, 1 ampoule/day, decocted with water. |
| Outcomes |
1. Symptoms (including palpitation, fatigue, emaciation, heat intolerance) of both groups improved obviousely. There was statistical significance between two groups;
2. Concentration of T3, T4 decreased and concentration of TSH increased obviousely in both groups. There was no statistical significance between two groups;
3. TGAb (TGAb>30%) / TMAb (TMAb>15%) negative turning rate of intervention group was better than control group. There was statistical significance between two groups. (I/C=31 (65.9%) /5 (15.6%) ) |
| Notes |
1. The formulation of Chinese medicine used in the intervention group was provided by the original authors;
2. There was potential conflict of interest in the study. |
