Comparison 2. Comparison of dose regimens.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 100 mg/kg x 5 days vs 200 mg/kg x 5 days	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1.1 All coronary artery abnormalities ‐ 0‐30 days	2	162	Risk Ratio (M‐H, Random, 95% CI)	1.76 [1.07, 2.89]
2.2 100 mg/kg x 5 days vs 400 mg/kg x 5 days	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.2.1 All coronary artery abnormalities ‐ 0‐30 days	3	401	Risk Ratio (M‐H, Random, 95% CI)	2.79 [1.59, 4.91]
2.2.2 All coronary artery abnormalities ‐ 31‐60 days	2	333	Risk Ratio (M‐H, Random, 95% CI)	3.14 [1.38, 7.15]
2.3 200 mg/kg x 5 days vs 400 mg/kg x 5 days	4		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.3.1 All coronary artery abnormalities ‐ 0‐30 days	4	623	Risk Ratio (M‐H, Random, 95% CI)	2.44 [1.49, 4.00]
2.4 400 mg/kg x 5 days vs 2 gm/kg single dose	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.4.1 All coronary artery abnormalities ‐ 0‐30 days	2	253	Risk Ratio (M‐H, Random, 95% CI)	4.47 [1.55, 12.86]
2.5 Fever 200 mg/kg x 3 days vs 400 mg/kg/day x 3 days	2		Mean Difference (IV, Random, 95% CI)	Subtotals only