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. 2019 Apr 2;294(21):8543–8554. doi: 10.1074/jbc.RA118.006983

Figure 3.

Figure 3.

Expression of Notch signaling pathway genes is deregulated in enzalutamide-resistant cells. A, heat map representing gene expression patterns of Notch signaling pathway genes in LNCaP versus MR49F cell lines. B, heat map representing gene expression patterns of Notch signaling pathway genes in C4-2 versus C4-2R cell lines. C and D, LNCaP, MR49F, C4-2, and C4-2R cells were treated with enzalutamide for 4 h and subjected to Western blotting analysis. E, 22RV1 cells were treated with GI254023X (ADAM 10 inhibitor) for 48 h and subjected to Western blotting analysis.