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Model of C5aR2 modulation of NLRP3 inflammasome activation and HMGB1 release in macrophages. C5a–C5aR2 contributes to NLRP3 inflammasome activation and HMGB1 release by elevating the expression of PKR via the MEK/ERK and IFN pathways. The cross-talk between C5aR2 and C5aR1 remains elusive in macrophages during NLRP3 inflammasome activation.
