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Model for antagonism by M013 via two structural domains. The N-terminal pyrin domain M013 is represented as an electrostatic surface, followed by the tail enriched in positively charged residues. The binding of M013 to its cellular targets is imparted by the two domains indicated by the boxed text above the model. However, antagonism of downstream signaling requires the interplay between both domains, as indicated by the dotted line connecting the two regions below the model.
