Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mutational analyses of vPOP M013 protein from myxoma virus
The results from NF-κB activation and caspase-1 activation in THP-1 cells are summarized: +, weak binding; ++, moderate binding; +++, strong binding; −, no binding. Details of the assays are described under “Experimental procedures.”
| Mutation | Interaction with ASC-1 | Interaction with NF-κB | NF-κB activation | Caspase cleavage |
|---|---|---|---|---|
| D41A | +++ | + | ++ | − |
| E28Q | − | ++ | − | +++ |
| D29N | + | + | ++ | ++ |
| D57N | + | + | − | + |
| M013PYD (delete 94–126) | ++ | + | +++ | − |
