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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Subcell Biochem. 2010;54:149–157. doi: 10.1007/978-1-4419-6676-6_12

Figure 4.

Figure 4

Model of the Pup-proteasome system. Following deamidation by Dop, Pup is ligated to substrate Lys via an isopeptide linkage to the C-terminal carboxylate of Glu. Ligation is shown on the γ-carboxylate for simplicity. Pup interacts with the AAA-ATPase Mpa, which presumably unfolds substrates for delivery into the catalytic chamber of the proteasome core for degradation. It is currently unknown whether additional factors are required for optimal conjugation and delivery to the proteasome, if PafA and Dop interact with the proteasome, or if Pup is recycled or degraded