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. 2019 May 22;16(154):20180887. doi: 10.1098/rsif.2018.0887

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© 2019 The Author(s)

Published by the Royal Society. All rights reserved.

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Figure 3. — Different aspects of the competition between codons for tRNAs. (a) One tRNA can recognize different codons with different affinities (top); similarly, several tRNAs can recognize the same codon with different affinities (bottom). The different affinities are emphasized by different colours. (b) tRNAs can be passively transported to the ribosomal A-site by diffusion or actively, by conformational changes of the ribosome induced by GTPase. (c) Successive usage of codons encoded by the same cognate-tRNA can improve the efficiency of local tRNA diffusion, as the ribosome can benefit from the vicinity of the tRNA that has just been used to translate the upstream codon. (Online version in colour.)