Table 3.
Dysregulated miR-15/107 family in human diseases
| miR-15a | miR-15b | miR-16 | miR-103 | miR-107 | miR-195 | miR-424 | miR-497 | miR-503 | sum | |
|---|---|---|---|---|---|---|---|---|---|---|
| Adrenocortical carcinoma | - | - | - | - | - | - | - | - | √ | 1 |
| Alzheimer's disease | √ | - | - | - | √ | - | - | - | - | 2 |
| Acute lymphoblastic leukemia (ALL) | - | - | - | - | - | - | √ | - | - | 1 |
| Acute myeloid leukemia (AML) | - | √ | - | √ | - | √ | √ | - | - | 4 |
| Acute promyelocytic leukemia (APL) | √ | √ | - | - | - | - | - | - | - | 2 |
| Autism spectrum disorder (ASD) | √ | √ | - | - | - | - | - | - | - | 2 |
| B-cell chronic lymphocytic leukemia | - | √ | - | - | - | - | - | - | - | 1 |
| Bladder cancer | - | - | - | - | - | √ | - | - | - | 1 |
| Breast cancer | - | - | - | - | - | √ | - | √ | - | 2 |
| Cardiac hypertrophy | - | √ | - | √ | √ | √ | √ | - | - | 5 |
| Cerebellar neurodegeneration | - | - | - | √ | - | - | - | - | - | 1 |
| Chronic lymphocytic leukemia (CLL) | √ | - | √ | - | √ | √ | √ | - | - | 5 |
| Chronic pancreatitis | - | - | - | - | - | √ | - | √ | - | 2 |
| Colorectal cancer | - | √ | - | - | √ | √ | - | √ | - | 4 |
| Endometriosis | - | - | - | - | - | - | √ | - | - | 1 |
| Epithelial ovarian cancer (EOC) | - | - | - | √ | - | - | - | - | - | 1 |
| Esophageal cancer | - | - | - | √ | √ | - | - | - | - | 2 |
| Gastric cancer (stomach cancer) | - | √ | √ | √ | √ | - | - | - | - | 4 |
| Glioma | √ | √ | √ | - | - | - | - | - | - | 3 |
| Heart failure | - | - | - | - | - | √ | - | - | - | 1 |
| Head and neck squamous cell carcinoma (HNSCC) | √ | - | - | - | - | √ | √ | - | - | 3 |
| Hepatocellular carcinoma (HCC) | √ | - | √ | - | √ | √ | - | - | - | 4 |
| Hodgkin's lymphoma | - | - | √ | - | - | - | - | - | - | 1 |
| Intrahepatic cholangiocarcinoma (ICC) | - | - | - | - | - | - | √ | - | - | 1 |
| Kidney cancer | √ | - | - | - | - | - | √ | - | - | 2 |
| Lung cancer | - | - | √ | - | - | √ | - | √ | - | 3 |
| Lupus nephritis | - | √ | - | - | - | √ | - | - | - | 2 |
| Malignant melanoma | √ | - | - | - | √ | - | - | - | - | 2 |
| Non-alcoholic fatty liver disease (NAFLD) | - | - | - | √ | √ | - | - | - | - | 2 |
| Non-small cell lung cancer (NSCLC) | √ | √ | √ | - | √ | - | - | - | - | 4 |
| Ovarian cancer (OC) | √ | - | √ | - | - | √ | √ | - | - | 4 |
| Oral Squamous Cell Carcinoma (OSCC) | - | - | √ | - | √ | - | - | - | - | 2 |
| Pancreatic cancer | - | √ | - | √ | √ | - | √ | - | - | 4 |
| Papillary thyroid carcinoma (PTC) | √ | - | √ | - | - | - | - | - | - | 2 |
| Pituitary adenoma | √ | - | - | √ | - | - | - | - | - | 2 |
| Polycystic Kidney Disease | √ | - | - | - | - | - | - | - | - | 1 |
| Polycystic liver disease | √ | - | - | - | - | - | - | - | - | 1 |
| Prostate cancer | √ | - | √ | √ | - | √ | - | √ | √ | 6 |
| Retinoblastoma | - | - | - | - | - | - | - | - | √ | 1 |
| Schizophrenia | √ | √ | - | - | √ | √ | - | - | - | 4 |
| Serous ovarian cancer | - | - | √ | - | - | - | - | - | - | 1 |
| Ulcerative colitis (UC) | - | - | √ | - | - | √ | - | - | - | 2 |
| Total (42) | 17 | 12 | 13 | 10 | 13 | 16 | 10 | 5 | 3 |
Diseases with more than 5 dysregulated miR-15/107 members were set in bold