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. 2019 May 31;13:50. doi: 10.1186/s13036-019-0180-5

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The lncRNA-mRNA co-expression network. The osteoporosis patients (OP) consisted of coexpression relationships between lncRNAs and mRNAs. The circles denote mRNAs and the square denote lncRNAs((green: downregulated genes; red: upregulated genes). The node degree is indicated by the circle size. An edge represents a coexpression relationship between mRNA and a lncRNA in the context of OP progression. Data were analyzed and constructed by Cytoscape software (The Cytoscape Consortium). This co-expression network suggests an inter-regulation of lncRNAs and mRNAs in OP development