Inclusion Criteria |
1) Diagnosis of advanced non-small cell lung cancer or inoperable pancreatic cancer |
2) Scheduled for systemic cancer therapy (i.e. chemotherapy, and/or targeted therapy and/or immunotherapy) |
i. In pancreatic cancer patients, planned systemic chemotherapy only allows of the combination of gemcitabine with nanoparticle paclitaxel. |
3) Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2 |
4) Age ≥ 70 years |
5) Body weight of 6 month ago can be confirmed |
6) An expected survival of ≥3 months as judged by investigators |
7) Written informed consent |
8) Adequate organ function |
i. Hemoglobin ≥8.0 g/dl |
ii. Total bilirubin ≤2.0 mg/dl |
iii. Aspartate aminotransferase ≤150 IU/L |
iv. Alanine aminotransferase ≤150 IU/L |
v. Serum creatinine ≤2.0 mg/dl |
vi. Arterial oxygen saturation (SpO2) ≥ 90% or partial pressure of oxygen in arterial blood (PaO2) ≥ 60 Torr in room air |
vii. Resting heart rate < 120 beat per minute |
Exclusion criteria |
1) Patients received prior chemotherapy except adjuvant chemotherapy |
2) Active malignancy requiring cancer treatment including chemotherapy, radiotherapy and surgery within 3 months |
3) Patients who need nursing care at following situation (based on Katz Index) |
i. Bathing |
ii. Dressing |
iii. Transferring |
iv. Feeding |
4) Symptomatic brain metastasis or leptomeningeal carcinoma |
5) Bone metastasis with high risk of fracture |
6) Patients who are difficult to evaluate or intervene with cardiovascular disease, bone and joint disease, neuromuscular disease etc. |
7) Patients who are difficult to participant due to psychiatric disorder |
8) Patients who are difficult to oral intake |
9) History of acute myocardial infarction, unstable angina, uncontrollable hypertension, and symptomatic sustained arrhythmia within 6 months. Stable atrial fibrillation treated with appropriate anticoagulation therapy is allowed. |
10) Uncontrollable diabetes mellitus |
11) Patients whose appropriate period has not passed since prior treatment |
i. Surgery: 7 days |
ii. Palliative radiation: 1 day |
iii. Minor surgery (i.e. biopsy): 1 day |
12) Screening failure |
i. Patients who failed to wear the accelerometer for more than 4 days |
ii. Patients who could not properly handle the accelerometer |
iii. Patients who failed to initiate first-line therapy within 14 days of enrollment |