Table 3.

Endpoints for the trial

Primary endpoint

The disability-free survival

Secondary endpoint

1) Lean body mass assessed by CT

2) Physical function assessed by the hand-grip strength, SPPB score and physical activity measured by accelerometer

3) Nutritional status assessed by body weight, MNA score and ingested nutritional quantity

4) Quality of Life assessed by EORTC-QLQ-C30

5) The proportion of patients treated with subsequent chemotherapy

6) Overall survival, Progression free survival

7) The cumulative number of days of hospitalization

8) Activity of daily life

9) Safety

CT computed tomography, SPPB short physical performance battery, MNA Mini Nutritional Assessment, EORTC-QLQ The European Organization for Research and Treatment of Cancer Quality-of Life Questionnaire