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. 2019 Jun 1;18:105. doi: 10.1186/s12943-019-1031-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — High TET1 expression inhibited the progression of HCC cells in vitro. a The expression of 5hmC and 5mC was detected in SMMC-7721 cells after transfection with circTRIM33–12 or the control using IF. b The expression of 5hmC and 5mC was detected in SMMC-7721 cells after transfection with TET1 or the control using IF. c Cell proliferation in HCC cells with the forced expression of TET1 was assessed by a CCK-8 assay. d The cell cycle in HCC cells with the forced expression of TET1 was detected by FCM. e The migration and invasion abilities in HCC cells with the forced expression of TET1 were evaluated via a transwell assay. The data are represented as the mean ± SD, n = 3. *P < 0.05; **P < 0.01