Table 1. Effect of rutin on serum liver markers in male rats intoxicated with CCl4.
| ALT (U/L) | AST (U/L) | ALP (U/L) | Bilirubin (gm/dl) | Protein (gm/dl) | Albumin (gm/dl) | |
|---|---|---|---|---|---|---|
| Control | 32.8a± 1.50 | 56.4a± 1.50 | 36.8a± 2.40 | 0.4a± 0.01 | 7.4a± 0.30 | 3.4a± 0.30 |
| CCl4 | 85.4b± 4.30 | 164.6b± 3.40 | 94.8b± 2.60 | 0.8b± 0.03 | 4.6b± 0.20 | 1.5b± 0.30 |
| Rutin | 30.2a± 2.30 | 56.0a± 2.90 | 38.4a± 2.70 | 0.5a± 0.01 | 7.6a± 0.20 | 3.5a± 0.20 |
| Rutin + CCl4 | 52.0c± 2.90 | 73.6c± 1.10 | 67.6c± 3.00 | 0.6c± 0.02 | 6.5c± 0.30 | 2.7c± 0.20 |
Data are expressed as mean ± SE of n = 5 rats/group. Different superscripts within the same column indicate significant differences between the groups (p ≤ 0.05). Treatments: control (vehicles); CCl4 (3 ml/kg b.w., by intraperitoneal route); rutin (70 mg/kg b.w., by gavage); both rutin + CCl4 co-treated group received CCl4 and rutin at the same doses twice a week for 4 weeks.
- AST
- aspirate transaminase
- ALT
- alanine transaminase
- ALP
- alkaline phosphatase