Table 4.
Tissue distribution of compound 35 (QCA570) in mice bearing RS4;11 xenograft tumors. Tissue distribution of compound 35 in mice bearing RS4;11 xenograft tumors. Each mouse had one tumor and was dosed with a single, intravenous dose of compound 35. Mice were sacrificed at 1, 3 and 6 hr time-points and different tissues were collected for analysis of drug concentration by LC/MS/MS. BLQ, below the limit of quantification.
| Concentrations of QCA570 in plasma (ng/ml) and tissues (ng/g) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| (IV, 5mg/kg) | Mouse 1 (1h) | Mouse 2 (1 h) | Mouse 3 (3 h) | Mouse 4 (3 h) | Mouse 5 (6 h) | Mouse 6 (6h) | Mean (1h) | Mean (3h) | Mean (6 h) |
| plasma | 1575 | 2360 | 47 | 263 | BLQ | BLQ | 1968 | 155 | BLQ |
| Tumor | 642 | 405 | 177 | 199 | 87.9 | 68.7 | 524 | 188 | 78 |
| Liver | 1227 | 1720 | 57 | 209 | BLQ | BLQ | 1473 | 133 | BLQ |
| Heart | 373 | 288 | 17 | 22 | BLQ | BLQ | 331 | 19 | BLQ |
| Kidney | 649 | 675 | 40 | 49 | BLQ | BLQ | 662 | 44 | BLQ |
| Lung | 1041 | 696 | 35 | 89 | BLQ | BLQ | 868 | 62 | BLQ |
| Intestine | 1283 | 1009 | 50 | 92 | BLQ | BLQ | 1146 | 71 | BLQ |