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Control compounds 21 and 22 fail to induce MDM2 degradation and show much weaker activity in cell growth inhibition in the RS4;11 cell line: (A) Chemical structures of 21 and 22; (B) Western blotting analysis of p53 and MDM2 proteins in RS4;11 cells treated with MI-1061, MD-224, 21 and 22; (C) Cell growth inhibition of MI-1061, MD-224, 21 and 22 in the RS4;11 cell line.
