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Pharmacodynamic (PD) analysis of MDM2, p53, p21 and PARP cleavage protein levels by western blotting after a single dose of MD-224 administered in the RS4;11 xenograft mouse model. A single dose of MD-224 (25 mg/kg, IV) effectively induces MDM2 degradation, p53 activation and PAPR cleavage in the xenograft RS4;11 tumors.
