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Western blotting analysis of the effect of potential MDM2 degraders with various linkers on induction of MDM2 and p53 proteins. RS4;11 cells were treated for 2 h with each individual compound at indicated concentrations and proteins were probed by specific antibodies. GAPDH was used as the loading control. MDM2 and p53 levels were quantified using an imager and were normalized over the GAPDH loading control.
