. Author manuscript; available in PMC: 2020 Jan 24.

Published in final edited form as: J Med Chem. 2018 Dec 10;62(2):448–466. doi: 10.1021/acs.jmedchem.8b00909

Table 1.

MDM2 degraders designed with various linkers to pomalidomide.


Compound No.	Linker	IC₅₀ (nM) in inhibition of cell growth in the RS4;11 cell line
MI-1061		141 ± 12
MI-1242		89 ± 12
1		10 ± 1
2		7 ± 2
3	Void (no linker)	68.4 ± 36
4		15 ± 2
5		9 ± 2
6		12 ± 2
7		22 ± 7
8		100 ± 27
9		8 ± 2
10		5 ± 1