Table 1.
Baseline demographics and CSF biomarkers
| Overall (n=239) | Females (n=125) | Males (n=114) | ||||
|---|---|---|---|---|---|---|
| APOEε4- (n = 98) | APOEε4+ (n = 27) | APOEε4- (n = 83) | APOEε4+ (n = 31) | Uncorrected group comparison p value | ||
| Mean (SD) | ||||||
| Age (years) | 74.3 (5.9) | 74.3 (5.6) | 72.9 (6.1) | 74.8 (5.5) | 73.9 (7.4) | 0.54 |
| Education (years) | 16.4 | 15.8 (2.5) | 16.2 (2.9) | 17.1 (2.5) | 16.5 (2.8) | 0.18 |
| Race (% white) | 90 | 89 | 93 | 93 | 87 | 0.71 |
| CSF Aβ1–42 | 1331.8 (651.4) | 1434.7 (652.6) | 999.2 (606.2)a | 1418.4 (587.5) | 1064.2 (706.7)a | <.001 |
| CSF t-tau | 239.8 (90.9) | 234.2 (96.5) | 283.4 (99.8)a | 221.9 (73.3) | 267.4 (93.1)a | <.001 |
| CSF p-tau | 22.0 (9.4) | 21.0 (9.2) | 27.8 (11.6)a | 20.1 (7.8) | 25.3 (9.8)a | <.001 |
| Aβ (% positive*) | 41 | 32 | 67 | 34 | 65 | <.001 |
CSF = cerebrospinal fluid, t-tau = total-tau, p-tau = phospho-tau.
*
Based on published cutoff: positive = <1100 pg/ml (Hansson et al., 2018).
a
significant difference between APOEε4+ and APOEε4−