(A) 3-D plot representing real-time RT PCR microarray analysis of 84 inflammatory genes. Columns pointing up (with z-axis values > 1) indicate an upregulation of gene expression, in the test sample (GPER KO) vs. control (WT). (B) Data represent those inflammatory genes significantly increased by 2-fold or more and P<0.05 in KO vs. WT hearts; n=3/group. Ifng, interferon gamma; Ptgs2, prostaglandin endoperoxide synthase 2; Pnax1, Pannexin 1; Ccl12, chemokine (C-C motif) ligand 12; Ccl15, Chemokine (CC motif) 5; Nlrp3, NLR family, pyrin 3; Pstpipi1, Proline-serine-threonine phosphatase-interacting protein 1; Il33, interleukin 33; Il18, interleukin 18.