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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Pharmacol Biochem Behav. 2019 Apr 13;181:28–36. doi: 10.1016/j.pbb.2019.04.004

Figure 1.

Figure 1

Dose responses of single administration of bupropion (BPP, 0, 5, 10 or 20 mg/kg) alone or combined with naltrexone (NTX, 0, 0.5, 1 or 2 mg/kg) on reducing 15% alcohol intake in both male and female B6 mice (n=6–8) in a 5-day drinking-in-the-dark (DID) model. Data were collected at the 4-hour time point on the baseline and testing day (24 hours later) and are expressed as a percentage of baseline alcohol intake to account for the differences in baseline that contribute to variation between experiments and sexes. **p<0.01 vs. control (both BPP and NTX at 0 mg/kg); ++p<0.01 vs. male mice with the same treatment; and #p<0.05 or ##p<0.01 vs. the BPP or NTX alone groups. Data shown are mean + SEM.