Table 3.

Effect of two (A) and four (B) repeat administrations of BPP+NTX (10+1 mg/kg) on 15% alcohol intake, water and preference ratio in male and female B6 mice after 3-week intermittent access (IA) alcohol drinking. On the test day, alcohol and water intake values were recorded after 4 hours of alcohol access. *p<0.05 vs. the vehicle-treated mice in the same sex; +p<0.05 vs. male mice with the same treatment. Data shown are mean ± SEM.

A. Two repeats	Male (n=7)		Female (n=7)
Treatment	Vehicle	BPP+NTX	Vehicle	BPP+NTX
Alcohol intake (g/kg/4h)	5.1 ± 0.33	3.4 ± 0.46 *	5.6 ± 0.23	5.0 ± 0.48 +
Preference ratio	0.80 ± 0.05	0.64 ± 0.05	0.85 ± 0.03	0.70 ± 0.10
Water intake (ml/4h)	0.11 ± 0.06	0.31 ± 0.09	0.26 ± 0.06	0.30 ± 0.09
B. Four repeats	Male (n=7)		Female (n=7)
Treatment	Vehicle	BPP+NTX	Vehicle	BPP+NTX
Alcohol intake (g/kg/4h)	4.8 ± 0.47	3.5 ± 0.40 *	5.4 ± 0.34	4.9 ± 0.17 +
Preference ratio	0.85 ± 0.03	0.70 ± 0.11	0.81 ± 0.04	0.70 ± 0.10
Water intake (ml/4h)	0.14 ± 0.09	0.39 ± 0.16	0.28 ± 0.10	0.49 ± 0.17