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Hyperpolarized 13C MR spectra over time illustrating hyperpolarized [1-13C]pyruvate to hyperpolarized [1-13C]lactate conversion in U87 cells (A). Temporal evolution of hyperpolarized [1-13C]lactate levels in U87 control and Vorinostat-treated cells (B). Quantification of hyperpolarized [1-13C]lactate production, as described in Methods section, [1-13C]Lacmax/Pyrmax, (C) [1-13C]LacAUC/PyrAUC (D) and kPL (E) in U87 control and Vorinostat-treated cells.
