Table 2.
Comparison of major postoperative complications between patients with synchronous versus metachronous peritoneal metastases who underwent CRS with HIPEC
| Synchronous colorectal PM (n = 231) n (%) |
Metachronous colorectal PM (n = 202) n (%) |
p value | |
|---|---|---|---|
| SAE score | 0.693 | ||
| 1–2 | 70 (30.3) | 56 (27.7) | |
| ≥ 3 | 62 (26.8) | 60 (29.7) | |
| Reoperation | 35 (15.2) | 30 (14.9) | 0.931 |
| Hospital mortality | 3 (1.3) | 4 (2.0) | 0.575 |
| Grade ≥ 3 complications | |||
| Anastomotic leakage | 15 (6.5) | 16 (7.9) | 0.589 |
| Postoperative bleeding | 3 (1.3) | 2 (1.0) | 0.714 |
| Intra-abdominal abscess | 28 (12.1) | 32 (15.8) | 0.379 |
| Wound infection | 5 (2.2) | 3 (1.5) | 0.468 |
| Urinary tract infection | 1 (0.4) | 2 (1.0) | 0.361 |
| Pneumonia | 3 (1.3) | 4 (2.0) | 0.549 |
| Other infection | 3 (1.3) | 8 (4.0) | 0.735 |
| Ileus | 6 (2.6) | 4 (2.0) | 0.630 |
| Gastroparesis | 5 (2.2) | 6 (3.0) | 0.650 |
| Electrolyte disorder | 0 (0.0) | 1 (0.5) | 0.636 |
| Anemia | 0 (0.0) | 0 (0.0) | 1.00 |
| Fistula formation | 2 (0.9) | 2 (1.0) | 0.660 |
| Wound dehiscence | 10 (4.3) | 7 (3.5) | 0.650 |
| Urinoma | 4 (1.7) | 1 (0.5) | 0.286 |
| Pulmonary embolism | 1 (0.4) | 0 (0.0) | 0.338 |
| Cardiac disease | 5 (2.1) | 3 (1.5) | 0.368 |
CRS cytoreductive surgery, HIPEC hyperthermic intraperitoneal chemotherapy, PM peritoneal metastases, SAE serious adverse event