Schematic overview of the treatment strategy for disseminated Ewing sarcoma. Bu busulfan, CPT-11 irinotecan, HDCT high-dose chemotherapy, IMRT intensity-modulated radiation therapy, Mel melphalan, SC stem cell, TMC topotecan, melphalan, and cyclophosphamide, TMZ temozolomide, VAI vincristine, actinomycin-D, and ifosfamide, VIDE vincristine, ifosfamide, doxorubicin, and etoposide