. 2019 Jun 1;18:131. doi: 10.1186/s12944-019-1074-8

Table 4.

Multivariable analysis of the association between FH and risk of MACCE

FH status^a	Participants (n)	MACCE (n)	Incidence rate (per 100 person-y)	Unadjusted HR (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)
No FH (Score < 3)	453	73	2.5	1.00 (Referent)	1.00 (Referent)	1.00 (Referent)
Possible FH (Score 3–5)	223	45	3.3	1.30 (0.89–1.88)	1.30 (0.90–1.89)	1.16 (0.77–1.75)
Probable/Definite FH (Score > 5)	30	9	5.8	2.34 (1.17–4.68)	2.39 (1.19–4.78)	2.30 (1.09–4.84)

FH status^a

Participants
(n)

MACCE
(n)

Incidence rate
(per 100 person-y)

Unadjusted
HR (95% CI)

Model 1
HR (95% CI)

Model 2
HR (95% CI)

No FH (Score < 3)

453

2.5

1.00 (Referent)

Possible FH (Score 3–5)

223

3.3

1.30 (0.89–1.88)

1.30 (0.90–1.89)

1.16 (0.77–1.75)

Probable/Definite FH

(Score > 5)

5.8

2.34 (1.17–4.68)

2.39 (1.19–4.78)

2.30 (1.09–4.84)

FH familial hypercholesterolemia, MACCE major adverse cardiovascular and cerebrovascular events, HR hazard ratio, CI confidence interval. Model 1, adjusted for age and sex. Model 2, adjusted for age, sex and cardiovascular risk factors, including current smoking, hypertension, diabetes mellitus, and BMI

^aBased on Dutch Lipid Clinic Network criteria