Table 2.
Upstream Regulators of the Upregulated Transcripts (n=727) Identified in Top Canonical Inflammatory Associated Pathways: IPA
| Progressed Upregulated n=364 | Not Progressed Upregulated n=363 | |||
| Top Canonical Pathways | p-value | Top Canonical Pathways | p-value | |
| Pathogenesis of MS | 1.31E-05 | Role of 17A in Psoriasis | 7.81E-05 | |
| EIF2 Signaling | 3.02E-05 | Histamine Degradation | 2.57E-03 | |
| Role of Hypercytokinemia/Hyperchemokinemia in the Pathogenesis of Influenza | 8.83E-04 | Inhibition of Angiogenesis by TSP1 | 5.44E-03 | |
| IL-9 Signaling | 1.36E-03 | Neuregulin Signaling | 6.43E-03 | |
| Communication between Innate and Adaptive Immunity | 3.11E-03 | |||
| Upstream Regulators | p-value | Upstream Regulators | p-value | |
| SAMSN1 | 1.36E-10 | Lipopolysaccharide | 8.29E-09 | |
| IFNLR1 | 9.87E-09 | TNF | 2.21E-08 | |
| STAT1 | 1.33E-09 | PGE2 | 1.68E-07 | |
| TBK1 | 1.35E-09 | CSF2 | 1.84E-07 | |
| IRF3 | 1.42E-09 | PD98059 | 3.33E-07 | |
| TLR3 | 1.46E-10 | Immunoglobulin | 5.28E-07 | |
| Salmonella enterica serotype | 1.92E-09 | IL2 | 9.43E-06 | |
| IFNA2 | 5.05E-09 | U0126 | 1.65E-06 | |
| TLR9 | 6.48E-09 | TGFB1 | 2.15E-06 | |
| STAT2 | 7.92E-09 | MYD88 | 2.70E-06 | |
| PTPRJ | 7.92E-09 | IL4 | 3.40E-06 | |
| IRF5 | 8.35E-09 | Diethylstilbestrol | 1.25E-05 | |
| DOCK8 | 1.01E-08 | EGR1 | 1.40E-05 | |
| IRF7 | 1.18E-08 | EGF | 1.46E-05 | |
| TMEM173 | 1.48E-08 | 9,10-Dimethyl-1,2-benzanthracene | 2.15E-05 | |
| TREM1 | 1.97E-08 | ATP-gamma-S | 2.17E-05 | |
| TLR4 | 2.07E-08 | Tretinoin | 2.28E-05 | |
| IFNAR1 | 2.16E-08 | LY294002 | 2.53E-05 | |
| IFNL1 | 5.57E-08 | Tributyrin | 2.74E-05 | |
| ELANE | 7.47E-05 | |||
| IL17A | 3.53E-05 | |||
| IL10 | 4.14E-05 | |||
| SMAD4 | 4.31E-05 | |||
| Methylprenisolone | 4.68E-05 | |||
| IL6 | 4.89E-05 | |||
| IL1 | 4.97E-05 | |||
| FoxP3 | 5.12E-05 | |||
| Alpha catenin | 5.56E-05 | |||