Table 1.
Item | Rasagiline Treated | Rasagiline Controls | Historical Controls41,42 | p-value* |
---|---|---|---|---|
Number participants | 60 | 20 | 177 | |
Number female (%) | 20 (33%) | 7 (35%) | 65 (37%) | 0.89 |
Number bulbar onset (%) | 10 (17%) | 3 (15%) | 44 (25%) | 0.29 |
Number taking riluzole (%) | 49 (82%) | 16 (80%) | 121 (68%) | <.001 |
Mean age in years (SD/range) | 58.4 (10.2 / 28–75) | 57.5 (8.5 / 40–73) | 57.3 (11.0 / 30–80) | 0.22 |
Mean symptom duration years (SD/range) | 1.23 (0.49 / 0.43–2.04) | 1.37 (0.46 / 0.52–2.05) | 1.06 (0.46 / 0.23–2.0) | 0.004 |
Mean baseline % predicted vital capacity (SD/range) | 92.5 (12.3 / 73–122) | 94.4 (12.5 / 75–124) | 94.9 (15.3 / 75–178) | 0.52 |
Mean baseline ALSFRS-R (SD/range) | 38.2 (6.1 / 17–48) | 35.9 (7.5 / 14–45) | 38.7 (4.8 / 23–47) | 0.08 |
P-value for 3 way ANOVA comparing treated, controls, and historical controls.