A- Representative RT-PCR gel demonstrating >50% decrease after siRNA treatment. Each panel demonstrates an amplification for the specified gene, and for each one, from left to right the lanes are as follows: USCs (no transfection), negative control siRNA cells, CBS siRNA, CTH siRNA, MPST siRNA. B- H2S production over 24 hours in USCs in normoxia and hypoxia (error bars are smaller than data points). *: p<0.0001 at the time point. C- H2S production expressed as a fold change from baseline over 24 hours in hypoxic conditions. *: p<0.05 vs. (−) control siRNA