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. 2019 Jan 29;188(6):1033–1054. doi: 10.1093/aje/kwz005

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Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health 2019.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 2. — Significance and direction of effects of index genetic variants identified at 18 novel loci for 3 lipid traits (high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG)) in a genome-wide meta-analysis of gene-alcohol interaction and lipid levels, 2017. For each combination of index variant and lipid trait, the effect direction of and P value for the most significant association is shown. For example, the rs11:63911273 variant was most significantly associated with HDL-C in the transancestry meta-analysis, using the “current drinker” alcohol consumption variable. Shades of purple and yellow represent negative and positive directions of effect, respectively, while associations of either direction with a P value greater than 0.05 are white. Effect +: the direction of effect is greater than or equal to zero; Effect –: the direction of effect is less than zero. df, degrees of freedom; ID, identification; rs, reference SNP; SNP, single nucleotide polymorphism.