Table 3.

Top Results of Ingenuity Pathway Enrichment Analysis for the 677 Replicated Cytosine-Phosphate-Guanine Sites Associated With Alcohol Consumption, Sister Study, United States, 2004–2015

Pathway	Permutation P Value
GM-CSF signaling	0.0003
Integrin signaling	0.0005
Role of macrophages fibroblasts and endothelial cells in rheumatoid arthritis	0.0006
Chronic myeloid leukemia signaling	0.0007
Germ cell–Sertoli cell junction signaling	0.002
Growth hormone signaling	0.002
NRF2-mediated oxidative stress response	0.002
Pancreatic-adenocarcinoma signaling	0.003
Virus entry via endocytic pathways	0.003
Hereditary breast cancer signaling	0.004
IGF-1 signaling	0.004
Paxillin signaling	0.005
FAK signaling	0.006
Glucocorticoid receptor signaling	0.006
MSP-RON signaling pathway	0.007
T-cell receptor signaling	0.007
Cardiac hypertrophy signaling	0.007
PKC-θ signaling in T lymphocytes	0.007
ErbB2-ErbB3 signaling	0.008
Regulation of eIF4 and p70S6K signaling	0.009
Leukocyte extravasation signaling	0.009
Telomerase signaling	0.01
Role of JAK1 and JAK3 in γc cytokine signaling	0.01

Abbreviations: eIF4, eukaryotic initiation factor-4; ErbB2-ErbB3, epidermal growth factor receptor tyrosine kinase B2 and B3; FAK, focal adhesion kinase; GM-CSF, granulocyte-macrophage colony-stimulating factor; IGF-1, insulin-like growth factor 1; JAK, ribosomal protein S6 kinase (p70S6K), Janus kinase; MSP-RON, macrophage-stimulating protein-protein tyrosine kinase/receptor d’origine nantais; NRF2, nuclear factor erythroid 2-related factor; p70S6K, ribosomal protein S6 kinase; PKC-θ, protein kinase C-θ.