Table 4.

Associations Between Total Average Methylation Across All Cytosine-Phosphate-Guanine Sites on the Array and Cytosine-Phosphate-Guanine Site Subgroups With Current Alcohol Consumption Level, Sister Study, United States, 2004–2015

Gene Region	Methylation Difference in %a
	Difference	P Value
All locations	−7.5 × 10−4	0.01
Gene body	−8.8 × 10−4	0.01
Other	−7.3 × 10−4	0.09
TSS1500b	−1.1 × 10−3	0.008
TSS200c	−1.8 × 10−6	0.66
5′UTRd	−1.2 × 10−3	0.0003
3′UTRe	−8.4 × 10−4	0.05

Abbreviations: TSS, transcription start site; UTR, untranslated region.

^aDifference associated with 1 additional alcoholic drink per week.

^b Within 1,500 base pairs of a transcription start site.

^c Within 200 base pairs of a transcription start site.

^d The 5′ untranslated region.

^e The 3′ untranslated region.