Table 5.

Top^a Cytosine-Phosphate-Guanine Sites With Associations Between Alcohol Consumption and DNA Methylation That Replicate in Both Blood and in Normal Breast Tissue Samples, Sister Study (2004–2015), Normal Breast Study (2009–2013), and the Cancer Genome Atlas (2012–2016), United States

Probe	Gene	Blood Discovery Set Methylation Coefficient	P Value	Breast Tissue Methylation Coefficient	P Value
cg02711608	SLC1A5	−0.007	4 × 10−12	−0.07	0.02
cg06180389	CD53	−0.003	5 × 10−11	−0.07	0.002
cg19566658	TRIP6	−0.004	4 × 10−10	−0.08	8 × 10−5
cg19939077	PPIF	−0.007	9 × 10−10	−0.06	0.006
cg19695041	TACC1	−0.003	1 × 10−9	−0.04	0.03
cg06745030	B3GNT7	−0.004	2 × 10−9	−0.08	0.003
cg02583484	HNRNPA1P10	−0.006	2 × 10−9	−0.08	0.001
cg16290996	SNORD75	−0.007	8 × 10−9	−0.09	0.015
cg11701312	MIR4754	−0.003	2 × 10−8	−0.06	0.009
cg03523740	TXLNA	−0.003	2 × 10−8	−0.05	0.004
cg02118194	MYPOP	−0.004	3 × 10−8	−0.05	0.0009
cg13105234	N/A	−0.005	1 × 10−7	−0.14	0.0001
cg17593384	AFF1	−0.003	2 × 10−7	−0.07	0.03
cg17962756	N/A	−0.004	2 × 10−7	−0.07	0.02
cg00326958	HNRNPF	−0.008	6 × 10−7	−0.05	0.03
cg10143507	N/A	−0.005	8 × 10−7	−0.05	0.001
cg06414073	GAS2L3	−0.003	1 × 10−6	−0.05	0.02
cg27479634	ATP5G2	−0.005	1 × 10−6	−0.06	0.003
cg23202985	N/A	−0.002	1 × 10−6	−0.12	4 × 10−7
cg22548088	MLLT1	−0.002	1 × 10−6	−0.04	0.02
cg08841048	ZNF428	−0.005	2 × 10−6	−0.07	0.03
cg23598378	C6orf132	0.003	3 × 10−6	0.09	7 × 10−5
cg09325711	RALA	−0.007	4 × 10−6	−0.10	0.02
cg03756485	GNPTAB	−0.003	5 × 10−6	−0.12	3 × 10−5

Abbreviations: AFF1, AF4/FMR2 family member 1; ATP5G2, adenosine triphosphate membrane subunit c2; B3GNT7, β-1,3-N-acetylglucosaminyltransferase 2; C6orf132, chromosome 6 open reading frame 132; CD53, CD53 molecule; GAS2L3, growth arrest specific protein 2-like 3; GNPTAB, N-acetylglucosamine-1-phosphate transferase subunits α and β; HNRNPA1P10, heterogeneous nuclear ribonucleoprotein A1 pseudogene 10; HNRNPF, heterogenous nuclear ribonucleoprotein F; MIR4754, microRNA 4,754; MLLT1, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog) (translocated to 1); MYPOP, Myb related transcription factor, partner of profiling; N/A, not applicable; PPIF, peptidyl-prolyl cis-trans isomerase; RALA, RAS-like proto-oncogene a; SLC1A5, solute carrier family 1 member 5; SNORD75, small nucleoloar RNA c/d box 75; TACC1, transforming acidic coiled-coil containing protein 1; TRIP6, thyroid receptor-interacting protein 6; TXLNA, taxilin α; ZNF428, zinc finger protein 428.

^a Blood association P ≤ 5 × 10−6.