Table 2.

Gene ontology annotation of infection response genes shows distinct differences in persistent shedding and low shedding animals.

Persistent shedders (PS)

Generally: intracellular response genes

↑ Response to biotic stimulus, immune resp.

↑ Proteasome, endopeptidase activity

↑ Protein catabolism

↑ Protein kinase cascade, reg. of NFkB cascade

↑ Programmed cell death, apoptosis

↑ Immunoglobulin domain

↑ Vacuole/lysozyme/lytic vacuole

↑ TOLL receptor signaling, NFkB/ILlR sig.

↑ Multiple sclerosis/diabetes/arthritis

↑ SH2 domain

↑ Pleckstrin

↑ Asthma/lupus-Genetic Assoc

↑ CHOLERA-Genetic Assoc

↓ Signal peptide

↓ Intrinsic to plasma membrane

↓ Signal transducer, receptor activity

↓ Extracellular matrix

↓ Morphogenesis, organ morphogenesis

↓ Cell-cell signaling

↓ Fibrinogen alpha/beta/gamma

↓ Ion channel activity

Low shedders (LS)

Generally: extracellular response genes

↑ Signal peptide, cell communication, receptor

↑ Response to biotic stimulus, immune resp.

↑ Integral to plasma membrane

↑ Extracellular matrix

↑ Cell-cell signaling, structural component

↑ Carbohydrate/heparin binding

↑ Angiogenesis

↑ Tissue/organ development/remodeling

↑ Fibronectin type III

↑ Organ morphogenesis

↓ Cell cycle, M phase

↓ Nucleosome, nucleus/nuclear protein

↓ Nucleic acid binding, reg. of biol. process

↓ Microtubule organizing center

↓ RNA localization, RNA splicing

↓ Response to DNA damage stimulus

↓ Chromosome segregation

↓ Cellular processes—phys., metabolic

↓ Zinc finger, ion binding