Table 4.

Influence of local relaxin (or vehicle) application by Bio‐Gide collagen scaffold on cranial lesion closure (lesion and scaffolding)

	BV‐2 (mm3)		TMD‐2 (g/cm3)
	V	R	V	R
Protocol 4	1.383 ± 0.126	1.515 ± 0.191	0.967 ± 0.019	0.964 ± 0.007
P‐value	0.586		0.899

Mean ± SEM. BV‐2, bone volume in lesion and scaffolding of surrounding area; TMD‐2, tissue mineral density of bone in lesion and scaffolding of surrounding tissue; V, vehicle; R, recombinant human relaxin. Protocol 4: mice were euthanized ~5 weeks after implementing 3.0 mm unilateral cranial lesions and applying scaffolds containing rhRLX (1.0 μg/scaffold) or vehicle (n = 4 mice each for relaxin and vehicle treatments).