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. 2019 May 16;16:106–121. doi: 10.1016/j.isci.2019.05.020

Figure 2.

Figure 2

Ad-GHRKO Exacerbates Dietary Obesity but Improves Glucose Homeostasis during HF Feeding

(A) Representative photographs of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks).

(B)The growth curves of Ad-GHRKO and Flox mice during RC or HF feeding.

(C) Increase in body weight (24 weeks versus 4 weeks) of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks).

(D) Fat tissue weight of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks).

(E and F) Fasting blood glucose levels of Ad-GHRKO and Flox mice fed with HF for 8 (E) and 16 weeks (F).

(G–J) Glucose tolerance test and insulin tolerance test of Ad-GHRKO and Flox mice fed with HF for 8 (G and H) and 16 weeks (I and J). Inset: The area under curves.

All values are presented as mean ± SEM. Statistical significance is shown as *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001. See also Figures S1 and S5 and Table S2.