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. 2019 May 16;16:106–121. doi: 10.1016/j.isci.2019.05.020

Figure 5.

Figure 5

Ad-GHRKO Alleviates Hepatic Steatosis during HF Feeding

(A–C) Liver mass (A), liver index (liver weight/body weight %) (B), and liver triglyceride content (C) of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks).

(D) Serum β-HBA levels of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks).

(E) H&E and oil red O staining of liver sections of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks). Scale bar, 100 μm.

(F) Serum AST and ALT activity of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks).

(G–J) Serum TG (G), T-CHO (H), LDL-C (I), and HDL-C (J) levels of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks).

(K) Relative gene expression levels in livers of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks).

(L) Western blot analysis of proteins involved in de novo lipogenesis, lipolysis, β-oxidation, and FFA uptake in livers of 24-week-old male Ad-GHRKO and Flox mice (HF fed for 16 weeks).

All values are presented as mean ± SEM. Statistical significance is shown as *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001. See also Figure S1 and Table S2.