Fig. 1.

Position in the left hemisphere sagittal plane (4 mm stride) of anchor MTL ROI elements of significant ROI pairs of interest in the EMCI – CN contrast (top) and mild AD – CN contrast (bottom). Shown are ROI masks for the 6-mm radius volume centered at the ROI seed. In both contrasts, ROIs group in a ventral anterior subzone and a dorsal posterior subzone. There is progressive change that may correlate with disease progression. In the mild AD – CN contrast, there are more significant ROI pairs of interest collectively whose anchor MTL ROIs cover a larger extent of the MTL compared to EMCI – CN. In addition, there is an increase in the number of individual MTL ROIs that form multiple significant ROI pairs in which one pair is of type hypoC and the other hyperC. Positions of the ROI paired with each MTL ROI shown are summarized in Table 3, their MNI coordinates are listed in Supplemental Tables 4 and 6, and corresponding image maps are shown Supplemental Figs. 6 and 7. The direction of ROI pair functional change is color-coded for hyperconnectivity (red), hypoconnectivity (blue), and simultaneous hyperconnectivity and hypoconnectivity (green). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)