Table 3.
Left MTL ROI - ROI pairwise significant MCI - CN comparisons.
| ANOVA (1-way, 3-levels) |
EMCI - CN post hoc t |
AD - CN post hoc t |
AD - EMCI post hoc t |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Anatomical Region(s) |
FDR p* = 0.026, q = 0.05, n = 50 |
Group Average Fisher Z Value |
FDR p* = 0.0168 |
FDR p* = 0.0214 |
FDR p* = 0.0364 |
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| MTL ROI | ROI | F | p | p* | CN | MCI | AD | p | d | p | d | p | d |
| ROI pair hyper-connectivity MCI vs CN | |||||||||||||
| L: Uncus, BA36, Hipp (EC) | L: BA38 | 11.3 | 0.00004 | 0.0000 | −0.03 | 0.18 | 0.24 | <0.001 | 0.92 | <0.001 | 1.09 | 0.1488 | 0.25 |
| L: Hipp (CA, FD) | R: BA38 | 8.7 | 0.00034 | 0.0010 | 0.05 | 0.13 | 0.23 | 0.0156 | 0.52 | <0.001 | 1.01 | 0.0138 | 0.52 |
| L: BA35, BA36, Hipp (SUB, CA) | R: Uncus, BA28, BA36 | 7.0 | 0.00145 | 0.0018 | −0.04 | 0.14 | 0.04 | <0.001 | 0.83 | 0.0406 | 0.42 | 0.0162 | 0.51 |
| L: Hipp (CA) | R: BA10, BA47 | 6.3 | 0.00252 | 0.0032 | −0.08 | 0.05 | −0.08 | 0.0016 | 0.66 | 0.4716 | 0.02 | 0.0006 | 0.80 |
| L: BA27, Hipp (FD, CA, SUB) | R:B A10, BA11 | 5.6 | 0.00489 | 0.0056 | 0.00 | 0.08 | −0.04 | 0.0168 | 0.52 | 0.1380 | 0.27 | 0.0012 | 0.74 |
| L: Uncus, BA36, BA28, Hipp (SUB) | L: BA34 | 4.4 | 0.01515 | 0.0188 | −0.06 | 0.08 | 0.06 | 0.0042 | 0.65 | 0.0096 | 0.57 | 0.3524 | 0.09 |
| ROI pair hypo-connectivity MCI vs CN | |||||||||||||
| L: Hipp (FD, CA, SUB), Ling. G. | L + R: Precuneus | 5.8 | 0.00424 | 0.0040 | 0.20 | 0.05 | 0.09 | 0.0002 | 0.79 | 0.0050 | 0.63 | 0.2098 | 0.19 |
| L: BA35, BA36, Hipp (SUB, CA) | L + R: Precuneus | 4.6 | 0.01187 | 0.0122 | 0.21 | 0.08 | 0.10 | 0.0034 | 0.68 | 0.0142 | 0.56 | 0.3586 | 0.09 |
| L: BA28, BA35, Hipp (SUB, EC, CA) | R: BA45, BA47 | 4.5 | 0.01291 | 0.0104 | 0.08 | −0.05 | 0.07 | 0.0098 | 0.58 | 0.4490 | 0.04 | 0.0040 | 0.64 |
| L: Caudate tail, Hipp (CA, FD) | L + R: ACC | 3.8 | 0.02570 | 0.0260 | 0.12 | 0.01 | 0.06 | 0.0016 | 0.71 | 0.0622 | 0.38 | 0.1258 | 0.27 |
ACC = anterior cingulate cortex; AD = Alzheimer's disease; CA = cornu ammonis; CN = cognitively normal; EC = entorhinal cortex; FD = dentate gyrus; FDR = false detection rate; Hipp = hippocampus; Ling. G. = lingual gyrus; MCI = mild cognitive impairment; MTL = medial temporal lobe; ROI = region of interest; SUB = subiculum.
Supplemental Information Table 6 (Worksheet EMCI-CN_Detail) provides additional details, including ROI MNI coordinates. Bold font indicates statistical significance under false-detection rate correction for multiple hypothesis testing.