. 2018 Jun 15;6(2):167–175. doi: 10.1016/j.gendis.2018.05.005

Table 1.

Effect of Sertraline, Meloxicam, Caffeic acid on monoamine neurotransmitter together with their precursor amino acids and metabolites (mean ± s, n = 5, μg/g).

	Tyr	MHPG	NE	5-HIAA	Trp	DA	DOPAC	HVA
Control	41.80 ± 9.19	1.50 ± 0.36	0.94 ± 0.05	0.19 ± 0.02	3.28 ± 0.57	0.15 ± 0.05	0.36 ± 0.04	0.18 ± 0.02
CUMS	123.71 ± 12.53^∗	2.41 ± 0.48^∗	0.74 ± 0.06^∗	0.24 ± 0.03^∗	5.08 ± 1.07^∗	–	0.58 ± 0.19^∗	0.33 ± 0.07^∗
Sertraline 5 mg/kg	128.09 ± 9.77^∗	2.48 ± 0.31^∗	0.65 ± 0.13^∗	0.14 ± 0.01^∗^#	10.38 ± 0.72^∗^#	–	–	–
Meloxicam 3 mg/kg	103.76 ± 7.87^∗^#	2.42 ± 0.28^∗	0.81 ± 0.15^∗	0.17 ± 0.02^∗^#	6.09 ± 1.68^∗	–	0.22 ± 0.06^∗^#	0.13 ± 0.01^∗^#
Meloxicam 1 mg/kg	93.71 ± 4.38^∗^#	1.82 ± 0.32^∗^#	0.67 ± 0.05^∗^#	0.16 ± 0.02^∗^#	5.84 ± 0.47^∗	–	0.18 ± 0.06^∗^#	0.13 ± 001^∗^#
Caffeic acid 30 mg/kg	52.96 ± 7.55^∗^#	2.27 ± 0.39^∗	0.80 ± 0.05^∗^#	0.15 ± 0.03^∗^#	3.62 ± 0.23^#	–	0.08 ± 0.01^∗^#	–
Caffeic acid 10 mg/kg	42.13 ± 8.50^#	1.77 ± 0.42^#	0.62 ± 0.01^∗^#	0.18 ± 0.04^#	4.90 ± 0.93^∗	–	0.18 ± 0.04^∗^#	–
Meloxica + Caffeic acid	109.09 ± 6.93^∗^#	1.95 ± 0.23^∗^#	0.61 ± 0.08^∗^#	0.17 ± 0.03^#	8.43 ± 0.80^∗^#	–	0.45 ± 0.16^#	0.23 ± 0.01^∗^#

Table note: *, P < 0.05, VS control group; ^#, P < 0.05, VS CUMS group.